Improvement of Function in the Aging Rat Hippocampus by Administration of Alanine-Glutamine Dipeptide as a Precursor of the Antioxidant Glutathione
Physiological aging and aging due to oxidative stress decrease alanine-glutamine dipeptide concentrations in plasma and hippocampus. These conditions impact the decreased availability of glutamine in intracellular and glutathione levels in the hippocampus. Decrease in hippocampal glutathione level will be followed by decreased function of hippocampal neuron. One way to improve the function of the hippocampus is to increase the availability of glutamic acid in hippocampal neuronal cells.