Biosafety and Biosecurity Devision

POTENTIAL OF GLUTATHIONE ANTIOXIDANT IN THE HIPPOCAMPUS REPAIR: PRELIMINARY STUDY ON BIOACTIVE MATERIALS ANTIAGING OF SNAKEHEAD FISH (CHANNA STRIATA) IN ANIMAL MODELS OF AGING

Snakehead fish meat contains active ingredients with anti-aging potential that serves as a precursor of glutathione. The ability of glutathione as an antiaging opportunities in the utilization of fish meat, especially snakehead fish. Snakehead fish meat contains several important amino acids, such as glutamine, cysteine, and glycine so the potential to be developed for the production of food that is nutritious and healthy. This study examines the essential amino acid composition of the antioxidant glutathione precursors found in snakehead fish from Rawa Pening Central Java to increase glutathione in the body and brain. The results showed that every 100g of snakehead fish meat from Rawa Pening containing glutamine (32.39%), cysteine (6.61%), and glycine (9.69%). Snakehead fish meat extract given at a dose of 30 ml/kg/day in both types of animal models of aging effect on the increase in the content of glutathione and glutathione precursors, both in blood and hippocampus. Increased glutathione precursor of the most high to low, respectively glutamine, glycine, and cysteine. Availability of essential amino acids can support increased glutathione in the brain. This is indicated by an increase in glutathione hippocampus in both animal models, both on chronological aging or aging due to oxidative stress, respectively (0.822 and 0.359) mol/g bb compared to control tissue.

Keywords— glutathione, glutamyne, glusine, cysteine, hippocampus, snakehead fish meat

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THE GLUTTATHION ROLE AS ANTIOXIDANT IN INHIBITION OF NEURODE GENERATIVE DISEASE AND BRAIN AGING

Neurodegeneratif disease and brain aging constitute problem that happen on many people nowadays. Study about endogen antioxidant toward this two case still little, thereby this papper will discuss about potenty of glutathione as endogen antioxidant. Glutathione as key phisiologycal parameter can be used indicator regard status of organ function especially for cases be related to neurodegeneratif disease andmn brain aging. In addition glutathione also known have role of important as body defence system toward free radical. Thereby this papper will discus information about neurodegeneratif disease and brain aging that its be related to glutathione, source of reactive oxygen species in body, glutathione potention, mechanism and function of glutathione, glutathione metabolism and glutathione metabolic interaction between astrocyte and neuron and its role for neurodegeneratif disease and brain aging inhibition. Finish discussion conclude that glutathione as endogen antioxidant own potention to free radical detoxification or reactive oxygen species, especially that be related to metabolism neuron and astrocyte cell in brain. Neuron and astrocyte cell in brain strongly mutual affect especially be related to glutathione metabolism and defence system toward reactive oxygen species. Glutathione system that be found astrocyte cell can contribute against brain defence and enhance neuron protection system against reactive oxygen species effect thus neurodegeneratif disease and brain aging can inhibited, (Sains Medika, 1 (2) : 185-210).

Keywords: glutathione, neurodegeneration, brain aging, astrocyte, neuron, reactive oxygen species

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